UCSF DIABETES, ENDOCRINOLOGY & METABOLISM TRAINING PROGRAM FACULTY RESEARCH SUMMARIES
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GRUNFELD, CARL, M.D., Ph.D. Department of Medicine
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My lab studies the metabolic disturbances due to infection, inflammation and their therapies. My basic science research focuses on the molecular mechanisms underlying the metabolic changes, their role in host defense and the consequences of chronic changes, such as promotion of atherosclerosis. My clinical research focuses on HIV infection, fat distribution and atherosclerosis risk factors, as well as metabolic changes in HIV patients. The roles of infection, therapy and restoration to health are outcomes our work assesses.
Selected References
Tien, P. and Grunfeld, C. What is HIV-associated lipodystrophy? Defining fat distribution changes in HIV infection. Curr. Opin. Infect. Dis. 17:27-32, 2004.
Khovidhunkit, W., Kim, M.S., Memon, R.A., Shigenaga, J. K., Moser, A.H., Feingold, K.R., Grunfeld, C. Effects of Infection and Inflammation on Lipid Metabolism: Mechanisms and Consequences to the Host. J. Lipid Res. 45:1169-96, 2004.
Khovidhunkit, W., Hachem, J. P, Medzihradszky, K.F., Duchateau, P. N. Shigenaga, J.K., Moser, A. H., Movsesyan, I., Naya-Vigne, J., Kane, J. P., R. Feingold, K. R., and Grunfeld, C. Parotid secretory protein (PSP) is an HDL-associated protein with anti candidal activity. Amer. J. Physiol. 288:R306-15, 2005.
Website: http://ncire.org/grunfeld.htm