Behavioral Medicine

Faculty Name: Judith Moskowitz, Ph.D., MPH. Subspecialty/ Research Focus: Coping with HIV and other chronic illnesses. Title of research project: The role of positive affect in adjustment to HIV. Brief description of project: A growing body of literature indicates that positive affect may have a unique adaptive role in the process of adjustment to chronic stress, independent of the effects of negative effects like depression. This study will document the occurrence, predictors, and consequences of positive affect during the 18 months postnotification of HIV+ serostatus. This is a longitudinal cohort study in which 250 participants recruited from 4 San Francisco Bay area sited will be interviewed 7 times over the course of 18 months after notification of HIV+serostatus. Data will consist of quantitative questionnaires, qualitative interviews (audiotaped), and CD4 and viral load measure. The specific aims of the study are: 1) Document the positive and negative affect in response to notification of HIV+ serostatus. 2) explore the potential adaptational significance of positive affect by examining its associations with adherence, HIV risk behaviors, healthcare utilization, health behaviors, role functioning, quality of life, and symptoms of clinical depression. 3) Identify coping processes and coping resources . 4) To explore the association of positive affect with cost of HIV treatment based on healthcare utilization and medication costs.

Cardiology

Faculty Name: Barry Massie, MD Phone: 415-750-2112 Fax: 415-379-5573 E-mail: barry.massie@va.gov Subspecialty/Research Focus: Cardiology, clinical trials and outcomes Title/Description of Research Project: The Heart and Soul Study Brief description of project: ICD outcomes research: We have a VA funded 5-year grant to determine the predictors of benefit or lack of benefit of ICDs in the VA system, as well as the cost-effectiveness of these devices. All ICDs implanted in the VA system are followed at the San Francisco VAMC by the VA National ICD Surveillance Center (Ed Keung Director), with the device implant and follow-up data being captured through each manufacturer's web-based system. These implants are occurring at a rate of 400-600/month. All patients are enrolled as patients at the San Francisco VAMC, so that clinical data can be abstracted from the VA electronic record and outcomes tracked via VA databases. A team of 4 research associates is building this database. In addition to the primary goals of this project, a number of shorter term and less extensive projects are feasible. Fellow involvement would involve some work on the database itself. I am the PI, with Paul Varosy leading much of the project. Other participants are Paul Heidenreich (Palo Alto VA, heading the economic aspects). Secondary manuscripts from clinical trials: I am the PI and have access to data from the Warfarin and Antiplatelet Trial in Chronic Heart Failure (WATCH) trial, which hopefully will be published in JAMA shortly. This is a 1500 patient trial in which patients with heart failure in sinus rhythm were randomized to warfarin, aspirin, or clopidogrel. We will begin analyses on secondary manuscripts shortly. I am also the PI of the I-Preserve trial. This is a 4,100 patient trial of irbesartan in patients with heart failure and EF >/= 45% (the largest such trial). The trial should reach its stopping point (1,440 events) in early 2008. We are preparing several manuscripts using baseline data, including 1 year outcomes in the entire population since relatively little is known of the natural history of this condition. Ultimately, many secondary manuscripts are planned but I don't anticipate that the final database will be available until late in 2008. I am also co-PI of the PROTECT trial. This is a 2,000 patient trial of patients admitted to for decompensated heart failure who have underlying renal dysfunction (eGFR <60-80) randomized to an adenosine antagonist or placebo. This agent appears to improve or prevent worsening of renal function and facilitate diuresis. Enrollment has been active and this will ultimately be a unique dataset for looking at cardiorenal interactions.

Faculty Name: Kirsten E. Fleischmann, MD MPH Phone: 415-476-6297 E-mail: fleischm@medicine.ucsf.edu Subspecialty/Research Focus: Cardiology; Outcomes research; Use of noninvasive tests; Heart failure; Secondhand smoke Title/Description of Research Project: Brief description of project: We have several projects available that are available for resident involvement. For example, we are currently studying several hundred UCSF outpatients with heart failure to assess the effects on secondhand smoke in this population. This rich database includes clinical information, test results, general and disease specific quality of life measures and long term follow-up. Residents could take ownership of several ancillary studies that have been built into our data collection or design their own project with supervision. More information on this and other studies available on request.

Faculty Name: Mary Whooley, MD Associate Professor of Medicine, Epidemiology and Biostatistics University of California, San Francisco Section of General Internal Medicine (111A1) Department of Veterans Affairs Medical Center 4150 Clement Street San Francisco, CA 94121 Phone: 415-750-2093 Fax: 415-379-5573 E-mail: mary.whooley@ucsf.edu Web site: http://www.heartandsoulstudy.net Subspecialty/Research Focus: Cardiovascular Disease, Quality of Life, Metal Health Title/Description of Research Project: The Heart and Soul Study Brief description of project: The Heart and Soul Study is a prospective cohort study of 1024 patients with coronary heart disease. Between 9/00 and 12/02, all subjects completed exercise treadmill testing with stress echocardiography, an extensive questionnaire, and several blood and urine measurements of cardiovascular disease risk factors. Participants are being followed for 8 yearrs to assess cardiovascular outcomes (MI, CHF, stroke). As of January 2006, UCSF residents and fellows have published over 20 papers from this dataset. Dr. Whooley has many idease for future research projects, and would be happy to help residents write and publish papers on these projects or others. Web site: http://dgim.ucsf.edu/heartandsoulstudy/

Faculty Name: Kendrick A. Shunk, M.D., Ph.D, FACC Assistant Professor of Medicine, UCSF Director, Cardiac Cath Lab, SFVAMC 415-750-2076 FAX 415-750-6950 Subspecialty/Research Focus: MR-guided cardiovascular interventions. Title of Research Project: Novel treatment methods for HOCM by MR-guided direct Intramyocardial EtOH injection. Brief Description of Project: In a large animal model we wish to test the hypothesis that, compared to ablation of HOCM by injection of EtOH into the first septal perforator branch (control group), that direct myocardial injections result in a more prescribed infarct pattern and avoid complications such as Complete heart block. The interested resident would obtain experience with a large animal research, catheter-based interventions, and MRI as a guidance and would be expected to take a leading role in the project from the beginning (obtaining appropriate approvals, etc.) through actual experiments to analysis and publication.

Faculty Name: Elyse Foster, M.D. Subspecialty/Research Focus: Cardiology/Echocardiology Title of Research Project: Various projects are available that could be tailored to the interest of the resident. Examples include: Echocariographic determinants of cardiac dyssynchrony and their relationship to benefit from cardiac resynchronization therapy in heart failure. Three-dimensional echocardiographic evalulation of mitral valve motion in patients with mitral regurgitation. Prognostic valve of echocardiographic variable of diastolic function. Brief Description: Both retrospective and prospective projects can be tailored to the interest of the resident.

Faculty Name: Andrew D. Michaels, M.D., FACC, FAHA, 415-502-2284 Subspecialty/Research Focus: Interventional Cardiology. Focus on clinical research involving hemodynamics and interventional therapies. Title of Research Project: Auscultation and Computerized Detection of Third and Fourth Heart Sounds. Brief Description of Project: I have generated a patient database through cross-sectional sampling of 100 patients undergoing cardiac catherization for a clinical indication. On the date of the procedure, each patient had a LV pressure recorded, and echocardiogram, BNP, blinded clinical auscultation by an attending, fellow, resident, and intern, and a computerized phonocardiogram that serves as the .gold-standard. for detection of a third an/or fourth heart sound. We have already compared the bedside clinical auscultation with the gold-standard. This next project would involve assessing the diagnostic accuracy of various physicians at different levels of training in detecting theses heart sounds with the following: 1) listening to the sound recording from each patient alone, 2) listening to the sound recording and looking at the phonocardiographic tracing, and 3) looking at the phonocardiographic tracing alone. The goal would be to determine if there is any difference in accuracy when a physician auscultates at the bedside, versus listening to a high-quality recording, versus listening to the recording plus seeing the phonocardiographic tracings. The implications would be a potential bedside method to improve detection of abnormal heart sounds.

Faculty Name: R. Teerlink, MD, FAAC, FAHA, FESC Contact information: Associate Professor of Medicine, UCSF Director, Heart Failure, SFVAMC SFVAMC, Cardiology 111C 4150 Clement Street San Francisco, CA 94121-1545 Phone: 415-221-4810, x4160 Email: john.teerlink@ucsf.edu Subspecialty/Research Focus: Cardiology, Heart Failure (Acute and Chronic) Clinical studies, clinical trials Regulatory Echocardiography New diagnostic devices for heart failure and ventricular function Title/Description of Project: The projects change rapidly, so please feel free to inquire, if interested in subject areas.

Faculty Name: Yerem Yeghiazarians, M.D. Contact Information: yeghiaza@medicine.ucsf.edu; office phone 415-353-3817 Subspecialty/Research Focus: Cardiology; Interventional Cardiology; Peripheral Vascular Disease; Vascular Biology; Cardiac Stem Cell Research Title/Description of Research Projects: After a myocardial infarction, loss of contracting heart muscle cells occurs resulting in scar formation and subsequently heart failure. Current therapies designed to treat heart attack patients in the acute setting include medical therapies and catheter-based technologies that aim to open the blocked coronary arteries with the hope of salvaging as much of the jeopardized heart muscle cells as possible. Unfortunately, despite these advances over the past 2 decades, it is rarely possible to rescue the at-risk heart muscle cells from some degree of irreversible injury and death. In addition, the delay in the time that most patients present to receive their care has been recognized as a major factor in the failure of current techniques in preventing significant cardiomyocyte injury. Attention has thus turned to new methods of treating heart attack and heart failure patients in both the acute and chronic settings after their event. Heart transplantation remains the ultimate approach to treating end-stage heart failure patients but this therapy is invasive, costly, some patients are not candidates for transplantation given their other co-morbidities, and most importantly, there are not enough organs for transplanting the increasing number of patients who need this therapy. As such, newer therapies are needed to treat the millions of patients with debilitating heart conditions. Recently, it has been discovered that stem cells, which are early progenitor cells with the ability to direct the production of all different types of human cells, may hold the therapeutic potential for these patients. Experimental studies in both animals and humans have revealed encouraging results when stem cells are injected into the heart in the areas of myocardial infarction. These therapies appear to result in improvement in the contractile function of the heart. Despite these promising early trials, many questions remain unanswered concerning the use of stem cells as therapy for patients with heart attack and heart failure. To answer these questions and to ultimately offer this therapy routinely to patients, the UCSF Cardiology Division has launched a Cardiac Stem Cell Translational Development Program to address these issues. We have numerous on-going projects in the small and large animal heart attack models; in-vitro experiments studying both adult and embryonic stem cell are underway; numerous observational human clinical trials are also currently being performed.

Faculty Name: Nelson Schiller, MD Contact Information: Phone: 353-1709 or schiller@medicine.ucsf.edu Subspecialty/Research Focus: Echocardiography (quantification of cardiac function, supine bicycle exercise, pulmonary hemodynamics, intraoperative TEE and outcome research through the Heart and Soul Study.Mary Whooley, MD PI) Title/Description of Research Projects: Have projects dealing with: Pulmonary pressure by noninvasive means.particularly pulmonary vascular resistance. Phonocardiography integrated with echocardiography.particularly first heart sound Adenosine augmented stress testing -- particularly supine bicycle exercise Quantification of left heart size and function -- particularly outcome of CAD in Heart & Soul study.

Emergency Medicine

Faculty Name: Christopher Fee, M.D. Contact information: Email: Christopher.Fee@ucsfmedctr.org Subspecialty/Research Focus: Emergency Medicine- Care of patients with pneumonia in the ED Identification and management of sepsis JCAHO pneumonia measures Brief description of research project: Effect of emergency department crowding on time to antibiotics for patients admitted with pneumonia Rate of inappropriate ED antibiotic administration to patients admitted for CHF in response to JCAHO pneumonia care measures Effect of ED boarding on care provided to patients admitted with pneumonia Identification of causative bacteria in septic patients using a 16s micro array

Faculty Name: John Stein, M.D. Subspecialty/Research Focus: Emergency Medicine/Use of Ultrasound in Emergency Setting Title of research project: Outcome research in the use of emergency ultrasound. Brief description of research project: A variety of issues in emergency ultrasound are currently being evaluated, and there is opportunity for new projects to start. Contact by email is preferable: jstein@medicine.ucsf.edu

Faculty Name:Martha L. Neighbor,MD Contact Information: mneighbor@sfghed.ucsf.edu 206-5748 Subspecialty/Research Focus (areas): Pain Management in the ED Racial and Ethnic Disparities in Pain Management Pain Management in Substance Users Anxiety and Pain Title/Description of Research Projects: "Characteristics of Pain in Chemically Dependent Patients in the Emergency Department" "Modification of Pain using Benzodiazepines in Anxious Patients"

Faculty Name: Robert M. Rodriguez, MD, Research Director Department of Emergency Services, SFGH Contact Information: rrodriguez@sfghed.ucsf.edu 206-5875 Subspecialty/Research Focus: My research interests are eclectic; I enjoy working with young investigators to develop their own ideas as they pertain to emergency medicine and critical care medicine. My particular areas of interest are 1) ICU/Emergency Department interface.interventions to improve outcomes in critically ill ED patients, 2) Acute Sepsis management, 3) Decision rules Title/Description of Research Projects: Derivation of a Clinical Decision Rule for Selective Chest Radiography in Blunt Trauma Patients The ICU Family Members Knowledge Study Fever in IV Drug Abusers Study Meta-analysis of Sgarbossa Criteria for AMI Prediction in the Presence of LBBB Acute ED Interventions for the Prevention of Post-traumatic Stress Disorder A Prospective Study of Stress Hyperglycemia in the Critically Ill Patient

End of Life Care

Faculty Name: Michael Rabow, M.D. Subspecialty/Research Focus: Palliative Care, End-of-life care, Medical Education, Professional Development, Humanity in Medicine Title of research project: Learning in the Valley of Death A cohort study of UCSF medical students from the Class of 2005 investigating the hidden curriculum in end-of-life care training. This project includes survey research from the entire class yearly since the second year and qualitative analysis from repeated interviews from a subset of students. Symptom Management and Palliative Care at the UCSF/Mount Zion Comprehensive Cancer Center This project is to perform a detail needs assessment among both patients and clinicians, and then to develop, implement, and evaluate a symptom management and palliative care consultation services.

Gastroenterology

Faculty Name: Scott Biggins, MD, MAS Contact Infomration: Division of Gastroenterologu 513 Parnassus Ave S-357 (Box 0538) San Francisco, CA 94143 Scott.Biggins@ucsf.edu Subspecialty/Research Focus: Hepatology and Liver Transplantation/Outcomes Research Title/Description of Research Projects My research efforts focus on exploring evidence-based improvements in recipient selection and organ allocation systems for liver transplantation. I conduct investigations of the manifestations and natural history of end stage liver disease, outcomes measures of liver transplantation, and medical ethics of organ transplantation.

Faculty Name: Marion Peters Contact Infomration: 415-476-2777 Marion.Peters@ucsf.edu Subspecialty/Research Focus: Hepatology Title/Description of Research Projects Clinical: Clinical studies in the role of alcohol in Hepatitis C infection; Co-infection of HIV patients with Hepatitis B and C; the role of liver disease in HIV infection. These studies evaluate the role of cofactors such as alcohol, HIV, drug use in outcome of disease and response to therapy. Studies on pathophysiology and management of end stage liver disease including autoimmune liver diseases, primary biliary cirrhosis and recurrent disease post liver transplantation. Studies on management of end stage liver diseases . Translational: Host-viral interactions in Hepatitis C and Hepatitis B infection. These projects evaluate clinical outcomes and the role of inflammatory cytokines and their receptors using DNA polymorphism analysis and mRNA gene profiling. We are studying the effect of the host response in induction of disease and response to therapy including the effect of alcohol and HIV co-infection.

Faculty Name: Hal Yee, M.D., Ph.D. Contact Infomration: Hyee@medsfgh.ucsf.edu Subspecialty/Research Focus:Gastroenterology/Health Services Research Title/Description of Research Projects: We are interested in the development and evaluation of interventions to improve access to specialty care, particularly in Safety-Net Healthcare Systems.

Faculty Name: Karen Seal, M.D., MPH Assistant Professor Department of Medicine 415-221-4810 x4852 FAX 415-379-5573 Subspecialty/Research Focus: Primary care internal medicine/Investigation of barrier to hepatitis C treatment among patients with substance use disorders and HIV co infection. Title of research project: Barrier to Eligibility and Acceptance of Treatment for HCV (BEAT HCV). Brief description of project: Revised national VA and NIH hepatitis C (HCV) treatment recommendations endorse HCV treatment for high-risk patients with substance use disorders and patients co-infected with HCV and HIV. Nevertheless, although this population is disproportionately affected by HCV, they are the least likely to receive HCV anti-viral therapy and are at increased risk for progressive liver disease and ongoing HCV viral transmission. We are conducting a cross-sectional survey study of 400 participants with substance use disorders and HIV co infection to ascertain the interventions to help close the gap between national policy and current practice. Assistance is needed with this exciting primary data collection project.

Faculty Name: Hal F. Yee, Jr., M.D., Ph.D. Subspecialty/Research Focus: Gastroenterology/Prevention and treatment of hepatic cirrhosis and intestinal strictures Title of research projects: Pathophysiology of hepatic cirrhosis Pathophysiology of intestinal stricture Epidemiology and management of chronic liver disease Brief description of research project: Molecular and cellular biology techniques are used to examine the pathophysiology of hepatic cirrhosis and intestinal strictures. Meta- and decision analysis, and database investigation are used to examine the epidemiology and management of chronic liver disease.

Faculty Name: Marion Peters, MD Contact Information: 415-476-2777 Subspecialty/Research Focus: Hepatology Title/Description of Research Projects: Role of alcohol in HCV infection Role of HIV in viral HCV infection Role of host responses in outcomes in liver transplantation Role of host response in viral hepatitis

Faculty Name: John M. Inadomi, M.D. Contact Information: Dean M. Craig Endowed Chair in Gastrointestinal Medicine Director, GI Outcomes and Health Services Research University of California, San Francisco Chief, Clinical Gastroenterology San Francisco General Hospital 1001 Potrero Avenue (3D5) San Francisco, CA 94110 jinadomi@medsfgh.ucsf.edu 415-206-4749 phone 415-641-0745 FAX Subspecialty/Research Focus: My primary research focus has been to examine the economic impact of competing management strategies to maximize outcome in environments with limited resources. Since this line of research is designed to prioritize resource allocation among competing strategies for different disease states, it has been necessary for me to examine multiple content areas in order to allow health care policy to be driven by evidence-based techniques. Thus, my research has spanned topics ranging from management of ascites and spontaneous bacterial peritonitis, Helicobacter pylori associations with peptic ulcer or gastric cancer, and cancer screening and surveillance. My recent work has focused on critically evaluating competing strategies for colorectal cancer screening and Barrett's esophagus and esophageal cancer screening. I have illustrated that numerous strategies to reduce mortality from colorectal cancer are substantially more cost-effective than current methods to decrease mortality from esophageal adenocarcinoma. The impact of my work has been to create national discussion about the need to increase colorectal cancer screening, offset by the need to question our policies regarding surveillance in Barrett's esophagus. My current work focuses on identifying the most important factors impacting the effectiveness of colorectal cancer screening, which includes the effect of patient adherence to competing screening strategies. The decision models we created consistently illustrate the primary importance of screening adherence in determining the optimal strategy for cancer screening - in other words, the outcome depends more on whether the patient is compliant with tests than on which test is employed. My current work examines barriers and facilitators to screening adherence and development of novel methods by which to increase adherence to colorectal cancer screening. It is my goal to use quantitative analytic techniques such as decision and cost-effectiveness analysis to summarize existing data in a usable form, and to identify areas upon which to concentrate clinical research. I also intend to utilize prospective methods to study these identified crucial areas in order to identify optimal methods by which to decrease mortality from gastrointestinal malignancy.

Faculty Name: Norah Terrault, MD, MPH Contact Information: Norah.Terrault@ucsf.edu ph: 476-2227 Subspecialty/Research Focus: Hepatology, Transplant Medicine Title/Description of Research Projects: Safety and efficacy of antiviral therapy of HCV-infected liver transplant recipients Retrospective cohort of patients with recurrent HCV infection who have been treated with interferon and ribavirin will be used to determine the safety of these drugs in this population and factors influencing treatment response. Predictors of long-term graft and patient survival in HCV infected liver transplant recipients. Retrospective cohort study of all patients transplanted at UCSF (1988-2006) to examine predictors of long-term graft and patient survival and in particular to examine the impact of de novo post-transplant diabetes on survival.

Faculty Name: Karen H. Seal Contact Information: SFVAMC-Box 111A1 (W) 415 221-4810 X4852 karen.seal@ucsf.edu or karen.seal@va.gov Subspecialty/Research Focus: Sub-Specialty: Primary care internal medicine Research Focus: Substance use disorders PTSD and mental health disorders among veterans returning from Iraq and Afghanistan Hepatitis C Title/Description of Research Projects: 1. The Neuropsychiatric Consequences of War among OEF/OIF Veterans A substantial proportion of veterans returning from Operations Enduring Freedom (OEF) and Operations Iraqi Freedom (OIF) suffer from one or more co-occurring mental health disorders. The VA has instituted an electronic clinical reminder to facilitate VA clinicians. conducting post-deployment screening to rapidly assess for PTSD, depression and high-risk alcohol use among OEF/OIF veterans. The primary scientific aims of this study are to validate the VA post-deployment screen by conducting telephone psychometric assessments using standardized instruments of 300 local OEF/OIF veterans. Secondary aims include: 1) to estimate the prevalence and predictors of positive screening tests for PTSD, depression and high-risk drinking, 2) to determine the proportion who receive mental health treatment and the predictors of receiving mental health treatment among OEF/OIF veterans who screen positive for a mental health disorder and 3) through telephone survey, to determine barriers to mental health treatment among OEF/OIF veterans 2. PTSD, Depression and Substance Use Disorders among OEF/OIF Veterans The VA and DoD collaborated to create a national VA OEF/OIF Roster in order to identify veterans of OEF/OIF who had enrolled in the VA healthcare system. This dataset may be linked to the VA National Patient Care database housed at Austin Automation Systems. To our knowledge, there have been no published reports using this newly available data. The aims of this project are to analyze the prevalence and nature of mental health disorders and describe mental health and overall health care utilization among OEF/OIF veterans. 3. Motivational Interviewing to Engage OEF/OIF Veterans in Mental Health Treatment The main aim of this randomized controlled trial is to evaluate the efficacy of telephone-administered motivational interviewing to enhance mental health treatment engagement among OEF/OIF veterans screening positive for one or more mental health disorders. 4. Testing and Services for Veterans Infected with Hepatitis C- Are We Optimizing Care for Veterans with Substance Use and Mental Health Disorders and HIV Coinfection? Using the VA Hepatitis C Registry database containing data on > 250,000 HCV (+) US veterans, this project will examine whether HCV (+) veterans with substance use and mental health disorders are receiving clinically recommended HCV-related testing and services.

Faculty Name: Phyllis C. Tien Contact Information: Infectious Disease Section, 111W 4150 Clement St SF, CA 94121 ptien@ucsf.edu 415-221-4810 ext 2577 Subspecialty/Research Focus: Metabolic complications (fat distribution changes, lipid and glucose abnormalities, and hepatic steatosis) of HIV and HCV coinfection Sex differences in metabolic complications of HIV Occult viral hepatitis infection

General Internal Medicine

Faculty Name: Elise Riley Contact information 415-206-4983 UCSF mailbox 1372 1001 Potrero Ave. Bldg. 100, Rm. 334 eriley@epi-center.ucsf.edu Subspecialty/Research Focus: Health disparities, health services use and health status (with an emphasis on HIV, HCV and HPV) among homeless and marginally housed adults. Title of Research Project: Shelter, Health and Drug Outcomes among Women (SHADOW). This is a study of the relationships between gender, housing status, drug use, mental illness and health service utilization, as well as their impact on health status in a population of HIV-infected marginally housed individuals. During the next study phase, there will be additional emphasis on predictors of HIV risk behavior and victimization. Cash Loss and Subsidies among the Homeless (CLASH). This study considers the effects of federal and county subsidies on the risk behavior of HIV-infected homeless and marginally housed persons. It compares individuals receiving and not receiving subsidies, using HIV-negative individuals as a control group. HIV, Environment and Risk among Unstably Housed Women Study (HERS). This study uses qualitative research methods to examine the ways in which housing situation contributes to the structural, social, and interpersonal dimensions of HIV risk environment. The Influence of Pharmacy-Based Syringe Disposal on the Health Risks of Injection Drug Users in California: The SB1159 Study. This is a multi-site study to evaluate the impact of county and city approved nonprescription pharmacy syringe sales on HIV risk, HIV infection, needle stick injuries among law enforcement and waste management personnel, crime in the vicinity of pharmacies, unsafe syringe disposal, and rates of illicit drug injection.

Faculty Name: Karron LeGarie Power, M.D.,MPH Subspecialty/Research Focus: Occupational and Environmental Medicine Title of Research Project: Effects of Ozone and Nitrogen Dioxide Exposure on Cardiovascular Responses in Healthy and Susceptible Humans. Brief Description of Project: To determine the effects of controlled exposure to Ozone and Nitrogen Dioxide on Heart Rate Variability, airway and systemic inflammation, components of the renninangiotensin system, and coagulability in healthy and asthmatic humans.

Faculty Name: Margaret Fang, M.D., MPH Subspecialty/Research Focus: Anticoagulation for atrial fibrillation, especially among older adults. Title of Research Project: Use and Outcomes of Anticoagulation among Frail Elders with Atrial Fibrillation. Brief Description of Project: This is a retrospective cohort study of frail, community dwelling elders with atrial fibrillation who are followed by On Lok Senior health care. We have identified approximately 200 patients with AF and the purpose of the study is to determine stroke and hemorrhage outcomes, as well as predictors of warfarin use among these patients. On Lok uses and electronic medical record to document all clinical care and collects information on patient race/ethnicity, language, social support, functional status, cognition, depression, and co morbid conditions. This, a wide variety of projects can be accomplished using this cohort.

Faculty Name: Stanton A. Glantz, Ph.D. Subspecialty/Research Focus: Cardiology/Tobacco Control Title of Research Project: Effects of secondhand smoke/smoking in the movies/tobacco control policy making. Brief Description of Project: We have a wide variety of projects under way ranging from reviews of the health effects of secondhand smoke (particularly, but not only on the cardiovascular system), through issues related to tobacco control policy making. I try and match the project to the interests and the time availability of individual residents.

Faculty Name: David Rempel, M.D.,M.P.H. (Professor in Residence) Subspecialty/Research Focus: Occupational Medicine/Hand and arm disorders related to work. Title of Research Project: Biomarkers for Carpal Tunnel Syndrome and Epicondylitis. Brief Description of Project: Evaluate the relationship between serum and urinary cytokines and severity (symptom and function) of carpal tunnel syndrome and epicondylitis. The goal is to identify biomarkers that are predictive of onset or worsening severity of these disorders in order to evaluate treatments and improve case management. Study takes place at the UCSF Hand Clinic and Occupational Medicine clinics in the Bay Area. Contact: drempel@itsa.ucsf.edu

Faculty Name: Elad Ziv, M.D. Subspecialty: General Internal Medicine Research Focus: Genetic Epidemiology, Genetics of Admixed Populations, Breast Cancer Epidemiology Title/Description of research projects: Genetics of Tamoxifen Response: This project will investigate the association between biomarkers of tamoxifen effect and estrogen receptor alpha polymorphisms among women in the UCSF SPORE cohort. Admixture and Breast Cancer Risk among Latinas This project investigates the association between breast cancer, breast density and genetic ancestry among Latinas. Admixed populations such as Latinas may be ideal for a technique called .admixture mapping. and this project will investigate the possibility of admixture mapping for breast cancer and breast density among Latinas.

Faculty Name: Alka Kanaya, M.D. Subspecialty/Research Focus: General Internal Medicine; several overlapping areas of interest include type 2 diabetes, obesity, metabolic syndrome, cardiovascular disease, and women's health. Title of Research Project: Several secondary data analyses available, or can be designed, looking at these topics of interest in available databases.

Faculty Name: Karla Kerlikowske, M..D. Subspecialty/Research Focus: Breast cancer screening. Risk factors for breast cancer. Title of research project: San Francisco Mammography Registry Brief description of research project: www.mammorgraphy.ucsf.edu/SFMR/

Faculty Name: Stephen Brent Contact Information: Email: Stephen.Brent@ucsf.edu Subspecialty/Research Focus: Complementary and Alternative Medicine Clinical Trials Systematic Review Title of research project: My primary research focus is the evaluation of the safety and efficacy of complementary and alternative therapies. Because there are few databases with complete information about herb and supplement use, most of the work in this area involves the development and execution of randomized controlled trials. Current studies include: Randomized controlled trial of valerian for the treatment of primary insomnia Omega-3 fatty acids for the treatment of autistic spectrum disorder Analysis of herb and supplement use among veterans attending anticoagulation clinics, and determining if there is an association between herb/supplement use and poor control of anticoagulation. Analysis of adverse event reports to poison control centers regarding herbs and supplements. I also have an interest in clinical trial methodology, and would be happy to assist in the development of resident/fellow projects in this area. In addition, I have conducted over a dozen meta-analyses, many of them with residents, and this can be a great first step towards developing expertise in a both a defined topic area and the skills of systematic review.

Faculty Name: Dean Schillinger, M.D. Associate Professor of Clinical Medicine Director, UCSF Center for Vulnerable Populations Contact Information: San Francisco General Hospital 1001 Potrero Avenue Building 10, Ward 13 San Francisco, CA 94110 Tel: 415-206-8940 Email: DSchillinger@medsfgh.ucsf.edu Subspecialty/Research Focus: Health communication, literacy, disparities, chronic disease, diabetes, language barriers, vulnerable populations. Title of research project: Multiple projects. Brief description of research projects: "Improving Diabetes Efforts Across Language and Literacy: Contextual Factors" "Development a Diabetes Self-Management Toolkit" "Patient Safety in Primary Care through Use of Interactive Technology Surveillance" "Health Literacy, Health Communication, and Chronic Disease Care" "Interactive Voice Response System to Transform Diabetes Care Among Vulnerable Populations" "The Role of Government in a National Health System, a Study of Chile" "Health Literacy & Self-Management in Heart Failure" "Harnessing Health IT for Self-Management Support and Medication Activation in a Medicaid Health Plan" "Disparities in Utilization and Outcomes in Rheumatoid Arthritis"

Faculty Name: Dean Schillinger, M.D. Associate Professor of Clinical Medicine 415-206-8940 FAX 415-206-5586 Email: dean@itsa.ucsf.edu Subspecialty/Research Focus: Chronic disease care, diabetes, communication, literacy, language, vulnerable populations. Title of research project: Multiple projects. Brief description of research projects: Multiple projects.

Faculty Name: Steven A. Schroeder, M.D. Distinguished Professor of Health and Health Care Department of Medicine Director, Smoking Cessation Leadership Center 415-502-1881 FAX 415-502-5739 Subspecialty/Research Focus: General Internal Medicine; tobacco control; smoking cessation activity by clinicians and health care organizations Title of research project: The Smoking Cessation Leadership Center Brief description of research project: Interested residents should review our web site: http://smokingcessationleadership.ucsf.edu

Faculty Name: Sunita Mutha, M.D. Subspecialty/Research Focus: General Internal Medicine/ Health Disparities, Organizational change, Cultural and linguistic competence Title of research project: Leading Organizational Change: Advancing Quality Through Culturally Responsive Care Brief description of research project: Racially and ethnically diverse populations predominantly receive their care in public health settings. Improving institutions. ability to provide quality care to multicultural populations offers the promise of reducing and eventually eliminating disparities in healthcare. The LEAD program is a three-year effort that uses key organizational change strategies to integrate culturally and linguistically competent care into California's public hospitals and health systems (CAPH). The specific objectives of the program are to: Develop and implement two cycles of a leadership training program for selected CAPH members. Provide grant funds to participating CAPH organizations. Create an electronic resource center to foster, document and disseminate tools and best practices for organizational change to state and national audiences; Provide coordinated technical assistance to program participants by UCSF faculty; and Document and disseminate emerging practices and policies to key audiences, including local and state public health departments, policy makers and national organizations.

Faculty Name: Eliseo J. Pérez-Stable, MD Contact Information: eliseops@medicine.ucsf.edu, 415-476-5369, Box# 0320 Subspecialty/Research Focus: Interests: Health and health care disparities, Aging research in African American and Latinos, Latino health care issues with an emphasis on cancer prevention, tobacco use and cessation, language and cultural factors in patient doctor communication, International health issues in Latin America and specially cigarette smoking cessation and prevention research in Argentina and Latin America Title/Description of Research Projects: Current projects: Existing data sets that include: Baseline and one-year follow up surveys of 3500 adolescents in Jujuy, Argentina on tobacco use and other factors; A survey of 970 women from 4 ethnic groups with an abnormal mammogram at baseline and one-year follow-up with chart reviews;, and A survey of 1,200 diverse women 40 to 79 years of age on communication of risk using three different cancer prevention topics and scenarios. Study evaluating the use of interpreters in a cardiology clinic and in an inpatient ward based at Alameda County Medical Center. Web-based smoking cessation intervention comparing different self-help interventions with several thousand participants from all over the world (English and Spanish)

Faculty Name: Ida Sim Contact Information: ida.sim@ucsf.edu Tel:415-502-1954 Subspecialty/Research Focus: clinical decision support systems informatics for evidence-based medicine informatics for clinical trials research and interpretation new models of scientific publication (open access, wikis, etc) health care policy and health services research health IT for quality improvement clinical trial registration and results reporting Title/Description of Research Projects: We have several projects that residents can work on with or without any computer programming ability. These projects deal mainly with designing new systems to help physicians use clinical trial results in patient care and to help researchers design better future trials. Any programming ability (e.g., web programming, Lisp, SQL) would be a plus but is not necessary. These projects are funded from the Trial Bank Project (http://rctbank.ucsf.edu), the National Center for Biomedical Ontology (http://www.bioontology.org), and the Electronic Primary Care Research Network (http://www.epcrn.bham.ac.uk) Title of Research Project: Trial Bank Project Description of Research Project:The Trial Bank Project captures detailed information about the design, execution, and results of randomized clinical trials (RCTs) into a computable Òtrial bankÓ knowledge base. Our Trial Bank uses medical informatics standards and semantic web technologies to capture, publish, and manage RCT information. We are demonstrating the value of computable RCT information for the following purposes: Which trials are relevant to my patient? using computable eligibility rules, standard vocabularies, ontologies, heuristic reasoning, etc. to determine applicability of trial evidence to electronic patient records What are other RCTs like this one and how are these trials similar or different? designing high-dimensional visualization interfaces of trial characteristics (see www.thechiselgroup.org/ctexplorer) What are related systematic reviews, guidelines, editorials, etc. to this trial? Was this a high quality, trustworthy trial? computer-assisted quality evaluation using CONSORT, Cochrane, GRADE, etc. criteria automatic flagging of protocol changes between trial registration and results reporting Title of Research Project: Trial Bank Reporting and Publishing Description of Research Project:Computers cannot read journal articles, which makes it difficult for decision support systems to help clinicians make sense of RCT reports. Trial Bank Publishing aims to change medical publishing so that RCTs are published as both prose articles and as trial bank entries. We have partnered with JAMA and Annals of Internal Medicine in the past. We are now working with the Public Library of Science (PLoS) on new models of open access, open data scientific publication. Related initiatives include Global Trial Bank (http://www.globaltrialbank.org), a non-profit organization affiliated with the American Medical Informatics Association (http://www.amia.org) on international informatics standards for interoperation of clinical trial information systems. Other interests and activities: Clinical Trial Registration and Reporting: : I used to lead the World Health OrganizationÕs International Clinical Trials Registry Platform project (http://www.who.int/ictrp), which sets international norms and standards for trial registration and reporting. There are a variety of open research questions relating to the ethical and scientific implications of biased trial reporting, the completeness and quality of trial registration and reporting, and global equity issues related to clinical trials research. Use of EMRs for quality improvement in primary care Informatics training and education: see http://ccti.ucsf.edu

Faculty Name: Eliseo J. Pérez-Stable, MD Contact Information: eliseops@medicine.ucsf.edu, 415-476-5369, Box# 0320 Subspecialty/Research Focus: Tobacco use and cessation Disparities by race/ethnicity Cancer control, screening and care Latino health care Language Access Title/Description of Research Projects: 1 P30 AG15272 (Pérez-Stable, PI) 09/30/1997- 06/30/2007 NIH/National Institute of Aging Center for Aging in Diverse Communities. The major goal of this study is to foster the development of investigators who will conduct research with older minority persons, develop and implement strategies to diversify the investigator workforce conducting research on the health of older minority persons, and develop and implement strategies for recruiting and retaining minority group members in research dealing with the health of minority elderly. P01 HS10856 (Washington, PI) 09/01/2000-08/31/2006 AHRQ (project #2/Pérez-Stable) Promoting Effective Communication and Decision-Making for Diverse Populations In this Program Project we will a) identify elements of effective communication in diverse populations; b) determine factors that enhance effective, patient-preference based, clinical decision-making; c) evaluate methods for communicating risks (probability and outcomes) in diverse populations; d) lay foundation for developing decision-assisting tools; and e) develop greater capacity for health services research. R01 TW05935 (Pérez-Stable, PI) 07/01/2002-6/30/2007 NIH/Fogarty International Center Tobacco Use Among Argentinian Youth: A Cohort Study The overall purpose is to assess factors associated with smoking initiation among Argentinian adolescents recruited at schools in the province of Jujuy. The grant also has a training component of Argentinian researchers. U01-CA 86117-04 (Ramirez, PI) 04/01/2000-03/31/2010 NIH/National Cancer Institute Redes En Accion: A Cancer Awareness, Research and Training Network The overall goal of the Redes En Acción will be to establish a national network of investigators and organizations focused on cancer in Latinos in order to increase awareness about cancer prevention and treatment, expand training opportunities for future investigators, and support new research ideas targeting Latinos. The California Endowment #20023080 ((Pérez-Stable, PI) 02/01/2003-01/31/2006 VideoConferencing Medical Interpretation Program The overall goal is to evaluate the implantation of a videoconferencing medical interpretation program at Alameda County Medical Center. Evaluations and process description will take place in the hospitalized patient, in a subspecialty clinic and in primary care setting. 2) Insert research statement My research theme is focused on health and health care disparities by race and ethnicity with a special emphasis on cancer prevention among Latino populations. Since 1993, I have been a leader of the Medical Effectiveness Research Center for Diverse Populations (MERC) in collaboration with A. Eugene Washington, MD. We lead a team of multidisciplinary investigators focused on health disparities by race/ethnicity with a special emphasis on cancer prevention, reproductive health, patient-doctor communication, and cardiovascular disease. Cigarette Smoking Cessation and Prevention. Since 1985 I have led projects that involve tobacco cessation and prevention. We completed a survey of California pediatricians and family physicians and compared their reported behavior in counseling adolescents about smoking cessation. For most evidence-based practices to promote smoking cessation, family physicians were significantly more likely to report these behaviors than pediatricians. A national survey of primary care physicians (stratified by Latino and White ethnicity) is completed and shows poor adherence to recommended cessation practices. I collaborate with Ricardo Muñoz, PhD on an innovative adaptation of a self-help smoking cessation intervention (developed by our group) combined with mood management components for a web-based intervention to be evaluated in a randomized trial. Recently funded for a third cycle to further develop an Internet based research program. Preliminary findings from the web-based intervention indicate cessation rates similar to those obtained with quit lines. A study of African American adolescents and a parent identified differential attitudes by tobacco exposure at home. In collaboration with the laboratory of Neal Benowitz, MD, we completed analyses of nicotine metabolism in 160 White, Latino, African American and Chinese American smokers. Comparison of Latinos to Whites showed no significant differences in nicotine metabolism or consumption, but Chinese smokers had lower clearance compared to Whites. Intake of nicotine per cigarette among Chinese smokers was significantly lower compared to Whites and Latinos (0.73 mg vs. 1.10 mg vs. 1,05 mg) and this may explain in part lower lung cancer rates in Chinese (ref #89). In 2002 we were funded by the Fogarty International Center of the NIH for a collaborative tobacco program with a university in Jujuy, Argentina. We completed data collection on 3500 10 to 12 year old children enrolled in schools to ascertain factors that predict smoking initiation. This is the first study of its type in Latin America. We are also analyzing the tobacco documents to evaluate legislation, court cases and policy issues in Argentina and have two papers published on this topic. Cancer Screening and Prevention. We are analyzing results of 970 interviews with women with an abnormal screening mammography examination stratified by four ethnic groups. The study is comparing psychological reactions, communication with the clinician, health related quality of life measures, and evaluation of index abnormality by four ethnic groups with adjustments for socioeconomic factors. Three initial manuscripts are submitted and under second review. The NCI funded Redes En Accion Network to address cancer prevention in Latino populations. We completed a survey of Latino leaders to identify priorities in cancer for Latinos, a national survey of Latino primary care physicians, evaluations of types of prostate cancer treatment by ethnicity and the role of support groups in Latinas with breast cancer. We are collecting data on 1600 women stratified by language and ethnicity to identify perception of risk in considering chemo prevention of breast cancer, screening of colon cancer and stopping cervical cancer screening after age 65. Minority Aging Research. The Center for Aging in Diverse Communities (CADC). provides infrastructure support for developing human capacity among minority investigators to conduct aging research. CADC funds 4 to 8 pilot studies per year and these have already led to publications. In collaboration we have also addressed the importance of race/ethnicity in research, recruitment of minority patients with cancer, and attitudes in interval cancer screening. We are currently conducting an evaluation of a video medical interpretation technology for limited English-proficient patients in three clinical settings and a church-based program to promote use of adult immunizations.

Faculty Name: Mary S. Beattie, MD Contact Information: email mary.beattie@ucsfmedctr.org; pager 719-8889 Subspecialty/Research Focus: General Internal Medicine and Women.s Health; Hereditary cancer, particularly BRCA1/2; hormones and breast cancer risk Title/Description of Research Projects: Endogenous sex hormones and breast cancer risk Hereditary Breast can Ovarian Cancer Predisposition: cohort study of over 1000 high rist participants with stored blood CREdIT: Cancer Risk Educational Intervention Tool: Study of a computer-based educational tool to educate patients at risk of hereditary cancer, particularly underserved populations Variants of Undetermined Significance in BCRA1/2: Collaboration with basic scientists to determine whether variants in BRCA1/2 are of low or high clinical significance Breast MRI for BRCA carriers: meta-analysis and cost effectiveness analysis Clinical trial of targeted chemotherapy for BRCA carriers with metastatic breast or ovarian cancer using a PARP inhibitor (phase II international trial)

Faculty Name: Doug Bauer, MD Contact Information: dbauer@psg.ucsf.edu Subspecialty/Research Focus: Clinical epidemiology projects related to diseases of older men and women: osteoporosis, thyroid disease, breast and prostate cancer, and functional decline. Particular emphasis on biomarkers. Title/Description of Research Projects: Multiple opportunities for secondary data analysis; can join existing project related to area of interest or review available datasets to formulate a new research question.

Faculty Name: Kenneth Covinsky, MD, MPH Contact Information: Ken.covinsky@ucsf.edu Subspecialty/Research Focus: Geriatrics Outcomes research/Epidemiology/Health Services Research Title/Description of Research Projects: We focus on understanding the determinants of major health outcomes in the elderly. We are particularly interested in the determinants of functional status outcomes and the use of functional status as a prognostic determinant of mortality and other health outcomes. We have a number of ongoing projects. Some are focused on understanding how a diverse range of risk factors predict outcomes in the elderly. Others are focused on developing and validating risk indices to accurately differentiate between elders at differential risk of adverse outcomes.

Faculty Name: Ralph Gonzales, MD Contact Information: phone: 514-0569; email: ralphg@medicine.ucsf.edu Subspecialty/Research Focus: Quality improvement Practice guideline development and implementation Management of acute respiratory tract infections in outpatient/acute care settings Appropriate antibiotic use activities Computerized applications to facilitate acute care and primary care services Title/Description of Research Projects: Minimizing Antibiotic Resistance in Colorado: Impact of office-based and mass media campaign on public knowledge/attitudes/behavior, antibiotic use and antibiotic resistance. Improving Antibiotic Use in Acute Care Settings (IMPAACT) Trial. 16-site randomized trial of provider/patient educational intervention to improve antibiotic use. And validation of a rapid, c-reactive protein test-based algorithm to improve diagnosis and treatment of acute cough illness. Implementation of a self-service computer kiosk for the management of uncomplicated UTIs in women.

Faculty Name: Ida Sim, MD, Ph.D. Contact Information: mailto:sim@medicine.ucsf.edu, 502-4519 Subspecialty/Research Focus: Medical Informatics -- decision support systems for evidence-based medicine, clinical trial registration and reporting systems, international policy for trial registration Title/Description of Research Projects: Trial Bank Project: The Trial Bank Project is a multifaceted project using ontology-based information technologies to publish and manage information from randomized clinical trials. Subprojects of the Trial Bank work include collaborations with medical journals to publish clinical trials as both e-text and as entries into "trial banks", high-dimensional visualization of trial characteristics, and automated matching of trial results to patient medical records. This project is part of the National Center for Biomedical Ontology and the National Electronic Clinical Research (NECTAR) network. Many projects are possible with and without any programming background, on how physicians use information from clinical trial results in clinical care, policy, and/or research. Clinical Trial Reporting and Registration: I lead the World Health Organization.s International Clinical Trials Registry Platform project (www.who.int/ictrp), which sets international norms and standards for trial registration and reporting. There are a variety of open research questions relating to the ethical and scientific implications of biased trial reporting, the completeness and quality of trial registration and reporting, and global equity issues related to clinical trials research.

Faculty Name: Elad Ziv, M.D. Contact Information: Box 1732 DGIM 1701 Divisadero St., Suite 537 San Francisco, CA 94115 Office: 415-353-7981 Email: elad.ziv@ucsf.edu Subspecialty: General Internal Medicine Research Focus: Genetic Epidemiology Identification of Common Genetic Variants Associated with Cancer Susceptibility Genetic Studies in Admixed Populations Genetics of Mammographic Density Breast Cancer Epidemiology Title/Description of Research Projects: Admixture and breast cancer risk among Latinas Genetics of Mammographic Density, a Strong Risk Factor for Breast Cancer Admixture mapping of inflammatory markers in African Americans Genetic variants that modify the effect of Tamoxifen

Faculty Name: Mallory O. Johnson, Ph.D. Contact Information: UCSF Center for AIDS Prevention Studies 50 Beale Street, Suite #1300 San Francisco, CA 94105 P: 415-597-9374 F: 415-597-9213 e-mail: Mallory.Johnson@ucsf.edu Subspecialty/Research Focus: Behavioral Medicine, HIV interventions Title/Description of Research Projects: 2005-Present Principal Investigator, A mindfulness approach to HIV treatment side effects. NIH/NCCAM R21. Co-Investigators: R. Hecht, T. Neilands, and J. Moskowitz. 2004-Present Principal Investigator, Measuring and understanding HIV treatment expectancies. UARP Grant. Co-PI: T. Neilands. 2004-Present Principal Investigator, NIMH R01 RCT of an HIV treatment side effects coping intervention. 4/1/2004-2/28/2009. Co- Investigators: S. Folkman, J. Moskowitz, T. Neilands. 2003-Present Co-Investigator, NIMH R01 Positive Affect in Adjustment to HIV. 12/1/2003- 1/30/2008. PI: Judith Moskowitz.

Faculty Name: Dean Schillinger, MD, Contact Information: Contact Info: 206-8940 Subspecialty/Research Focus: Dean Schillinger, MD, is Associate Professor of GIM at UCSF, and is based at SFGH. Dr. Schillinger has extensive expertise in translational research and advocacy with respect to vulnerable populations. He is a national expert in health communication-related research, particularly the relationships between literacy, communication, and chronic illnesses. He has completed both descriptive and translational research in the areas of diabetes care, heart disease, and is also carrying out epidemiologic research regarding educational disparities in chronic disease care in the US and abroad. He is a member of the UCSF Center for Health and Community, UCSF Primary Care Research Center, and UCSF Medical Effectiveness Research Center, and is an adjunct member of the N. California Kaiser Division of Research. He was honored with the 2003 Institute for Healthcare Advancement Research Award for this work. He was recently awarded grants from the California Endowment, the Commonwealth Fund, NIH, and the ACP Foundation to develop and evaluate disease management programs tailored to the literacy and language needs of diabetes and heart disease patients. Dr. Schillinger contributed to the 2004 Institute of Medicine Report on Health Literacy and is a member of the Joint Commissions Patient Safety Scientific Advisory Board. He completed an Open Society Institute Advocacy Fellowship working with California Literacy, Inc, a non-profit educational organization that helps people gain literacy skills, to advance the California Health Literacy Initiative.

Faculty Name: Karen H. Seal Contact Information: SFVAMC-Box 111A1 (W) 415 221-4810 X4852 karen.seal@ucsf.edu or karen.seal@va.gov Subspecialty/Research Focus: Sub-Specialty: Primary care internal medicine Research Focus: Substance use disorders PTSD and mental health disorders among veterans returning from Iraq and Afghanistan Hepatitis C Title/Description of Research Projects: 1. The Neuropsychiatric Consequences of War among OEF/OIF Veterans A substantial proportion of veterans returning from Operations Enduring Freedom (OEF) and Operations Iraqi Freedom (OIF) suffer from one or more co-occurring mental health disorders. The VA has instituted an electronic clinical reminder to facilitate VA clinicians. conducting post-deployment screening to rapidly assess for PTSD, depression and high-risk alcohol use among OEF/OIF veterans. The primary scientific aims of this study are to validate the VA post-deployment screen by conducting telephone psychometric assessments using standardized instruments of 300 local OEF/OIF veterans. Secondary aims include: 1) to estimate the prevalence and predictors of positive screening tests for PTSD, depression and high-risk drinking, 2) to determine the proportion who receive mental health treatment and the predictors of receiving mental health treatment among OEF/OIF veterans who screen positive for a mental health disorder and 3) through telephone survey, to determine barriers to mental health treatment among OEF/OIF veterans 2. PTSD, Depression and Substance Use Disorders among OEF/OIF Veterans The VA and DoD collaborated to create a national VA OEF/OIF Roster in order to identify veterans of OEF/OIF who had enrolled in the VA healthcare system. This dataset may be linked to the VA National Patient Care database housed at Austin Automation Systems. To our knowledge, there have been no published reports using this newly available data. The aims of this project are to analyze the prevalence and nature of mental health disorders and describe mental health and overall health care utilization among OEF/OIF veterans. 3. Motivational Interviewing to Engage OEF/OIF Veterans in Mental Health Treatment The main aim of this randomized controlled trial is to evaluate the efficacy of telephone-administered motivational interviewing to enhance mental health treatment engagement among OEF/OIF veterans screening positive for one or more mental health disorders. 4. Testing and Services for Veterans Infected with Hepatitis C- Are We Optimizing Care for Veterans with Substance Use and Mental Health Disorders and HIV Coinfection? Using the VA Hepatitis C Registry database containing data on > 250,000 HCV (+) US veterans, this project will examine whether HCV (+) veterans with substance use and mental health disorders are receiving clinically recommended HCV-related testing and services.

Faculty Name: Ralph Gonzales Contact Information: email: ralphg@medicine.ucsf.edu; office phone: 514-0569 Subspecialty/Research Focus: health services research; quality improvement; acute illness management; appropriate antibiotic use Title/Description of Research Projects: Measuring the Clinical Performance of Recent UCSF Medicine Residency Graduates, Examination of non-antibiotic prescribing for acute respiratory tract infections (ARIs) (bronchitis, pharyngitis, sinusitis, URIs) in EDs, Predictors of Return ED visits for ARIs, Updating the CDC "Principles of Appropriate Antibiotic Use for Adults with Acute Respiratory Tract Infections"

Faculty Name: Pamela Ling, MD MPH Contact Information: Assistant Professor, Department of Medicine Director, Tobacco Control Policy Fellowship Center for Tobacco Research and Education University of California San Francisco Box 1390 530 Parnassus Avenue, Suite 366 San Francisco, CA 94143-1390 Phone (415) 514-1492 FAX (415) 514-9345 email: pling@medicine.ucsf.edu Subspecialty/Research Focus: Tobacco use among young adults Tobacco marketing to women Applying market research strategies to public health interventions Social marketing, counter-marketing and media campaigns Title/Description of Research Projects: Tobacco documents research on marketing to young adults and/or women. Residents can conduct tobacco documents research, but generally this requires at least a 1 month research commitment in addition to RSP time. Qualitative/analytical analysis of previously secret tobacco industry documents to describe what tobacco companies know about smoking among young adults and women, and to identify areas for intervention, counter-marketing campaigns. We are looking primarily at domestic (USA) strategies, but can accommodate interest in globalization and/or foreign countries if a resident/fellow has appropriate background and interest. National market research survey of young adult smoking. We have collected the data on a national sample of approximately 1500 young adults, which includes many lifestyle questions and measures of what movies young adults watch. A resident/fellow could analyze and write up part of this data. Topics include: smoking in movies and young adult smoking, psychographics of young adults, social smoking patterns and associations, social norms and young adult smoking, Focus groups testing receptivity to anti-tobacco messages among different psychographic subgroups of young adults. A resident could participate in the qualitative phase of the young adults study, help to collect data and/or analyze focus group data (project to be done this year), Pilot study of tailored smoking cessation messages based on what brands patients smoke. Can cessation messages be tailored depending on if a patient smokes light cigarettes (education about the fallacy of lights being safer) versus other brands (such as emphasizing cost saving to patients who smoke cheap cigarettes). Can education about the deceptive marketing practices of the tobacco industry motivate cessation? We are developing a tailored intervention along these lines for pilot testing. Two possible application models include tailored clinical interventions or tailored cigarette warning labels. This project would require a substantial time commitment, at least a research month in addition to RSP time.

Faculty Name: Beth Kaplan MD Contact Information: 206-5757, bkaplan@sfghed.ucsf.edu Subspecialty/Research Focus: intimate partner violence, sexual assault, rapid HIV testing, diagnosis of ectopic pregnancy

Faculty Name: Steve Schroeder Contact Information: Steve.schroeder@ucsf.edu Subspecialty/Research Focus: Smoking Cessation Title/Description of Research Projects: The Smoking Cessation Leadership Center, works with multiple health professional organizations to help smokers quit. We have published many articles on the subject, have lots of projects underway, and could explore ways to tailor a project that would meet the interests and time requirements of the resident. A significant new project for the upcoming year will be to work with mental health professionals so that they can do a better job helping their patients quit smoking

Faculty Name: Seth Landefeld Contact Information: sethl@medicine.ucsf.edu, 514-0715 Subspecialty/Research Focus: Geriatrics Health Care Research Health Care Improvement Title/Description of Research Projects: Determinants of Outcomes of Hospitalized Older Persons: Secondary analyses can be performed to identify determinants of functional and quality of life outcomes at discharge and during the subsequent year. Examples: Walter LC, Brand RJ, Counsell SR, et al. Development and validation of a prognostic index for 1-year mortality in older adults after hospitalization. JAMA 2001; 285: 2987-94. Holroyd-Leduc JM, Sands LP, Counsel SR, Palmer RM, Kresevic DM, Landefeld CS. Risk factors for indwelling urinary catheterization among older hospitalized patients without a specific medical indication for catheterization. J Patient Safety 2006; 1:201-7

Faculty Name: Michael W. Rabow, MD Contact Information: mrabow@medicine.ucsf.edu Pager: 719-4206 Subspecialty/Research Focus: Specialty: General Internal Medicine and Palliative Care Research focus: palliative care, including outpatient palliative care, medical student and physician professional development Title/Description of Research Projects: Developing and evaluating palliative care in the Comprehensive Cancer Center. Includes clinical, interdisciplinary consultation, patient discussion groups, RN continuing educ. Research includes evaluation of staff/MD satisfaction, as well as a planned RCT of patient depression, anxiety, and QOL in the setting of palliative care consultation vs usual care Physician-Family Caregiver Project - A collaboration between Osher and the Dept of Neurosurgery. Producing a documentary film about family caregiving and developing a web-based training module for neurosurgery residents on supporting family caregivers. Research includes effectiveness evaluation of resident training sessions, documentation of dissemination The Healer.s Art Evaluation - National evaluation of the impact of the Healer.s Art elective, now offered at UCSF and 44 other medical schools nationwide. Current project is qualitative analysis of student mission statements. Planned: evaluation of faculty experience nationally.

Genetics

Faculty Name: Wen-Chi Hsueh, MPH, Ph.D. 415-885-7397 FAX 415-885-7724 Subspecialty/Research Focus: Genetic epidemiology of complex traits related to aging and metabolism Title of research project: Please refer to these 2 websites: http://www.ucsf.edu/hsueh/ http://www.gcrc.ucsf.edu/Wen-Chi%20Hsueh.htm

Geriatrics

Faculty Name: Michael Steinman, M.D. 415-221-4810 x3677 FAX 415-750-6641 Email: mstein@itsa.ucsf.edu Subspecialty/Research Focus: Geriatrics. Research interests include: measurement of prescribing quality in elders inappropri ate use of antibiotics in outpatient infections pharmaceutical marketing. Title of research project/Brief description of project: I have several research projects related to my research interests, and would be happy to discuss them individually with interested residents.

Faculty Name: Kenneth Covinsky, MD, MPH Contact Information: Ken.covinsky@ucsf.edu Subspecialty/Research Focus: Geriatrics Outcomes research/Epidemiology/Health Services Research Title/Description of Research Projects: We focus on understanding the determinants of major health outcomes in the elderly. We are particularly interested in the determinants of functional status outcomes and the use of functional status as a prognostic determinant of mortality and other health outcomes. We have a number of ongoing projects. Some are focused on understanding how a diverse range of risk factors predict outcomes in the elderly. Others are focused on developing and validating risk indices to accurately differentiate between elders at differential risk of adverse outcomes.

Faculty Name: Seth Landefeld Contact Information: sethl@medicine.ucsf.edu, 514-0715 Subspecialty/Research Focus: Geriatrics Health Care Research Health Care Improvement Title/Description of Research Projects: Determinants of Outcomes of Hospitalized Older Persons: Secondary analyses can be performed to identify determinants of functional and quality of life outcomes at discharge and during the subsequent year. Examples: Walter LC, Brand RJ, Counsell SR, et al. Development and validation of a prognostic index for 1-year mortality in older adults after hospitalization. JAMA 2001; 285: 2987-94. Holroyd-Leduc JM, Sands LP, Counsel SR, Palmer RM, Kresevic DM, Landefeld CS. Risk factors for indwelling urinary catheterization among older hospitalized patients without a specific medical indication for catheterization. J Patient Safety 2006; 1:201-7

Hematoloy/Oncology

Faculty Name: Donald I. Abrhams, M.D. Email: dabrams@hemonc.ucsf.edu Subspecialty/Research Focus:: Integrative oncology Oncology in underserved populations Title/Description of Research Projects: Potential chart review projects involving a descriptive assessment of patients coming to the UCSF Osher Center for Integrative Medicine for Integrative oncology consultation Outcomes of SFGH oncology patients as impacted by concomitant HIV, HBV, HCV infection and/or homelessness

Faculty Name: Charles J. Ryan MD Contact information ryanc@medicine.ucsf.edu Subspecialty/Research Focus: Oncology, Prostate Cancer Hormonal therapies for prostate cancer Developmental Therapeutics Title of research: My research deals with the mechanisms of resistance to standard hormone therapy for prostate cancer patients. As a clinical/translational researcher, I conduct clinical trials of new drugs at the phase I and II level. My major clinical trials target the synthesis of androgens by the adrenal gland. Further, I study the interaction of androgen stimulation and signaling by the Insulin like growth factor (IGF) receptor in prostate cancer models. We do preclinical work in the lab that corresponds to our ongoing clinical trials.

HIV

Faculty Name: Jason Barbour, Ph.D., MHS. Positive Health Program, Department of Medicine San Francisco General Hospital University of California, San Francisco 995 Potrero Ave.,Ward 84 San Francisco, CA 94110 Phone 415-476-4082 x425 Fax: 415-476-6953 UCSF Campus Box 0874 Subspecialty/Research Focus: Immune Activation in HIV Disease Title of Research Project: Viral and Host Determinants of Variation in Immune Activation in HIV-1 Infected Adults. Brief Description of Project: We are seeking to determine viral and host genetic determinants of variation in immune activation levels observed individuals Infected wit the HIV-1. Immune activation level in response to infection is the chief predictor of rate of disease progression, and treatment response. However, the basis of the variation in activation, and disease progression rates, is not understood. We perform population based studies to statistically Identify genetic correlates. We then perform basic science studies to elucidate mechanism and identify targets for modulation of activation levels.

Faculty Name: Laurence Huang, M.D. Associate Professor of Medicine Chief, AIDS Chest Clinic San Francisco General Hospital Mailing address: Positive Health Program, Ward 84 San Francisco General Hospital 995 Potrero Avenue San Francisco, CA 94110 Telephone: (415) 476-4082 extension 406 Fax: (415) 476-6953 E-mail: Lhuang@php.ucsf.edu Subspecialty/Research Focus: HIV- Associated Pulmonary Disease, Pneumocystis Pneumonia (PCP) Title of research project: Molecular Epidemiology Studies of Pneumocystis Pneumonia Brief description of research project: Dr. Huang's main clinical and clinical research interests are in HIV-associated pulmonary disease and especially Pneumocystis pneumonia (PCP). He has several collaborations with researchers at the Centers for Disease Control and Prevention, the National Institutes of Health, the University of Cincinnati, the University of Alabama- Birmingham and the University of Southern California as well as independent studies on PCP and ICU outcomes among HIV-infected patients. Current research studies include: A multicenter molecular-epidemiology study investigating the association between Pneumocystis prophylaxis, Pneumocystis cannot be cultured, this study seeks to address the question of whether human Pneumocystis develops evidence of resistance to PCP treatment and prophylaxis regimens. Development and validation of several new molecular applications to PCP, including the use of a quantitative PCR assay and a novel RT-PCR molecular viability assay on oropharyngeal wash specimens to diagnose PCP, development of Pneaumocystis antibody assays, and development of a .cytokine flow cytometry. assay to detect Pneumocystisspecific CD4+ and CD8+ T cell immune responses. Comprehensive molecular-epidemiology study to address the question of whether PCP in humans results from person-to-person transmission (as has been convincingly demonstrated from animal-to-animal laboratory studies) and whether disease results from reactivation of latent infection or from recent exposure and infection. Prospective cohort study of the incidences, persistence, and consequences of Pneumocystis colonization both for the individual under study as well as for the potential as a reservoir for the organism. Prospective cohort study of the incidence and persistence of Pneumosystis colonization among health care workers (HCW). Creation of an international Pneumocystis network to enable researchers to pool resources and share data to answer questions of mutual interest and to estimate the contribution of PCP to morbidity and mortality in HIV-infected persons worldwide.

Faculty Name: Dr. Mark Jacobson Contact Information: Mark A. Jacobson, M.D. Professor of Medicine in Residence Positive Health Program University of California, San Francisco Ward 84, 995 Potrero San Francisco General Hospital San Francisco, CA 94110 415-476-4082 ext 407 FAX 415-476-6953 Subspecialty/Research Focus: Dr. Mark Jacobson is a Professor of Medicine in Residence at University of California, San Francisco (UCSF). He has previously been Director of the UCSF Adult AIDS Clinical Trials Unit and of the UCSF Center for AIDS Research Clinical Core and is now associate director of the General Clinical Research Center at SFGH. Dr. Jacobson did an Infectious Diseases fellowship at the University of California, Los Angeles, before joining the UCSF faculty in 1986. His major research interests are in the immunopathogenesis, natural history and treatment of AIDS-related opportunistic infections and in immune reconstitution of HIV-infected patients who have received highly active antiretroviral therapy. Residents can work with Dr. Jacobson on observational studies (involving medical record review).

Faculty Name: Laurence Huang, M.D. Contact Information: Positive Health Program, Ward 84 San Francisco General Hospital 995 Potrero Avenue San Francisco, CA 94110 Telephone: (415) 476-4082 extension 406 Fax: (415) 476-6953 E-mail: Lhuang@php.ucsf.edu Subspecialty/Research Focus: Pulmonary Title of Research Project: Molecular Epidemiology Studies of Pneumocystis Pneumonia Description of Research Project: Dr. Huang's main clinical and clinical research interests are in HIV-associated pulmonary disease and especially Pneumocystis pneumonia (PCP). He has several collaborations with researchers at the Centers for Disease Control and Prevention, the National Institutes of Health, the University of Cincinnati, the University of Alabama- Birmingham and the University of Southern California as well as independent studies on PCP and ICU outcomes among HIV-infected patients. Current research studies include: A multicenter molecular-epidemiology study investigating the association between Pneumocystis prophylaxis, Pneumocystis cannot be cultured, this study seeks to address the question of whether human Pneumocystis develops evidence of resistance to PCP treatment and prophylaxis regimens. Development and validation of several new molecular applications to PCP, including the use of a quantitative PCR assay and a novel RT-PCR molecular viability assay on oropharyngeal wash specimens to diagnose PCP, development of Pneaumocystis antibody assays, and development of a .cytokine flow cytometry. assay to detect Pneumocystisspecific CD4+ and CD8+ T cell immune responses. Comprehensive molecular-epidemiology study to address the question of whether PCP in humans results from person-to-person transmission (as has been convincingly demonstrated from animal-to-animal laboratory studies) and whether disease results from reactivation of latent infection or from recent exposure and infection. Prospective cohort study of the incidences, persistence, and consequences of Pneumocystis colonization both for the individual under study as well as for the potential as a reservoir for the organism. Prospective cohort study of the incidence and persistence of Pneumosystis colonization among health care workers (HCW). Creation of an international Pneumocystis network to enable researchers to pool resources and share data to answer questions of mutual interest and to estimate the contribution of PCP to morbidity and mortality in HIV-infected persons worldwide.

Hospital Medicine

Faculty Name: John Stein, M.D. Subspecialty/Research Focus: Emergency Medicine/Use of Ultrasound in Emergency Setting Title of research project: Outcome research in the use of emergency ultrasound. Brief description of research project: A variety of issues in emergency ultrasound are currently being evaluated, and there is opportunity for new projects to start. Contact by email is preferable: jstein@medicine.ucsf.edu

Faculty Name: Niraj L. Sehgal, MD, MPH Contact Information: nirajs@medicine.ucsf.edu (415)476-0723 Subspecialty/Research Focus: Hospital Medicine. Patient Safety and Quality Improvement, Interprofessional communication and teamwork Title/Description of Research Projects The TOPS (Triad for Optimal Patient Safety) Project is a pilot study targeting 14-Long that involves a large quality improvement project directed at providers and a research component directed at patients. The QI portion of the project involves a series of patient safety interventions with an overall goal to improve safety culture. The interventions include formal teamwork and communication training, monthly unit-based activities to reinforce the training, and interventions targeting patients by engaging them in patient safety education. The research component of the project involves recruitment of patients on 14-Long with a series of interviews during hospitalization and after discharge to assess their hospital experience and specifically address components of safety, teamwork, and communication. In addition, chart abstractions are being performed to capture addition demographic and clinical data. The TOPS project is a joint endeavor with the School of Nursing and Pharmacy at UCSF and we are directing identical efforts at two collaborating sites: Kaiser-SF and El Camino Community Hospital in Mountain View. QI projects around discharge planning and communication between different healthcare professionals

Faculty Name: Andrew D. Auerbach, M.D., MPH. Subspecialty/Research Focus: Perioperative medicine, risk prediciotn, translating research into practice, biomarkers. Title of research projects: Novel Biomarkers of Perioperative Risk Novel Biomarkers of Perioperative Risk: This prospective trail of patients undergoing major noncardiac surgery at UCSF seeks to understand whether preoperatively measured levels of a variety of biomarkers (e.g. IL-6, CRP, TNF-alpha) predict risk for postoperative complications (MI, Pneumonia, delirium, surgical site infection) mortality, after adjusting for traditional clinical risk factors (e.g.age, co morbidities). Understanding and improving perioperative quality of care at UCSF Understanding and improving perioperative quality of care at UCSF: Using a data collection strategy similar to that for project 1, this large prospective trial seeks to understand the current gaps in delivering appropriate care for patients undergoing major noncardiac surgery, in particular 1) Use of perioperative beta blockers, 2) DVT prophylaxis, 3) Diabetes management, and 4) Prevention of surgical site infections.

Infectious Diseases

Faculty Name: Kimberly page Shafer Contact information: Email: kshafer@psg.ucsf.edu; 597-4954 Subspecialty/Research Focus: Epidemiology and prevention of HIV and HCV infections; vulnerable populations (youth, IDU, MSM, CSW); international settings Title of Research Project: Acute HCV infection in young injectors: UFO Study Studying youth in Northern California (SYNC) Chemoprophylaxis for HIV Prevention: preparation for HIV prevention trials (Thailand) Young WomenÕs Health Study Ð Phnom Penh Cambodia (HIV epidemiology and prevention). HCV in incarcerated and recently incarcerated populations.

Faculty Name: Philip Rosenthal, M.D. Phone: 415-206-8845 Email: prosenthal@medsfgh.ucsf.edu Subspecialty/Research Focus: ID/Malaria Title of Research Project: Clinical and molecular epidemiology of antimalarial drug research. Brief Description of Project: We have multiple projects, which can be broadly descried as: Clinical trials of antimalarial therapies in Uganda Studies of clinical and molecular epidemiology of malaria and antimarlarial drug resistance. Basic science studies pf the biology and biochemistry of malaria parasites, and Antimalarial drug discovery.

Faculty Name: Lisa Winston, M.D. Assistant Clinical Professor UCSF Department of Medicine Infectious Diseases Division 415-206-8703 Subspecialty/Research Focus: Infectious Diseases. Research focus: hospital epidemiology, antibiotic resistant bacteria. Title of research project: Clinical failures of MRSA treated .adequately. with vancomycin. Oral versus parenteral antibiotics for osteomyelitis. Brief description of project: Chart and electronic record review to determine failure rate and risk factors in patients who were appropriately treated for MRSA. Other questions also possible, including proportion of patients who do/do not receive recommended therapy. Meta-analysis versus structured literature review to evaluate whether parenteral antibiotics are superior for osteomyelitis and if so, under what circumstances. Other projects gladly discussed.

Faculty Name: Mallory O. Johnson, Ph.D. Contact Information: UCSF Center for AIDS Prevention Studies 50 Beale Street, Suite #1300 San Francisco, CA 94105 P: 415-597-9374 F: 415-597-9213 e-mail: Mallory.Johnson@ucsf.edu Subspecialty/Research Focus: Behavioral Medicine, HIV interventions Title/Description of Research Projects: 2005-Present Principal Investigator, A mindfulness approach to HIV treatment side effects. NIH/NCCAM R21. Co-Investigators: R. Hecht, T. Neilands, and J. Moskowitz. 2004-Present Principal Investigator, Measuring and understanding HIV treatment expectancies. UARP Grant. Co-PI: T. Neilands. 2004-Present Principal Investigator, NIMH R01 RCT of an HIV treatment side effects coping intervention. 4/1/2004-2/28/2009. Co- Investigators: S. Folkman, J. Moskowitz, T. Neilands. 2003-Present Co-Investigator, NIMH R01 Positive Affect in Adjustment to HIV. 12/1/2003- 1/30/2008. PI: Judith Moskowitz.

Faculty Name: Dr. Mark Jacobson Contact Information: Mark A. Jacobson, M.D. Professor of Medicine in Residence Positive Health Program University of California, San Francisco Ward 84, 995 Potrero San Francisco General Hospital San Francisco, CA 94110 415-476-4082 ext 407 FAX 415-476-6953 Subspecialty/Research Focus: Dr. Mark Jacobson is a Professor of Medicine in Residence at University of California, San Francisco (UCSF). He has previously been Director of the UCSF Adult AIDS Clinical Trials Unit and of the UCSF Center for AIDS Research Clinical Core and is now associate director of the General Clinical Research Center at SFGH. Dr. Jacobson did an Infectious Diseases fellowship at the University of California, Los Angeles, before joining the UCSF faculty in 1986. His major research interests are in the immunopathogenesis, natural history and treatment of AIDS-related opportunistic infections and in immune reconstitution of HIV-infected patients who have received highly active antiretroviral therapy. Residents can work with Dr. Jacobson on observational studies (involving medical record review).

Faculty Name: Phyllis C. Tien Contact Information: Infectious Disease Section, 111W 4150 Clement St SF, CA 94121 ptien@ucsf.edu 415-221-4810 ext 2577 Subspecialty/Research Focus: Metabolic complications (fat distribution changes, lipid and glucose abnormalities, and hepatic steatosis) of HIV and HCV coinfection Sex differences in metabolic complications of HIV Occult viral hepatitis infection

Information Technology

Faculty Name: J. Ben Davoren, M.D., Ph.D. Associate Clinical Professor of Medicine, UCSF Division of Hematology/Oncology Director, Clinical Informatics, San Francisco VA Medical Center 4150 Clement Street, San Francisco Box 111-H1 San Francisco, CA 94121 Phone: 415-221-4810 x3424 Email: davoren@itsa.ucsf.edu OR ben.davoren@med.va.gov Subspecialty/Research Focus: Impact of electronic medical records on patient outcomes or hospital/clinic practices. Utility of electronic medcial record information in decision-making. Medical oncology outcomes. Title of Research Project/Brief Description: The Computerized Patient Record System (CPRS) used in the VA is populated with very dense data, containing essentially all clinical information on our patients since 1998. That information can be used to test basic hypotheses in case-control studies, retrospective cohort studies, test assumptions about prevalence and incidence, etc. CPRS can also be used as an interventional tool (for example, randomizing different providers or types of providers to different order sets, menus, progress note templates, or methods of data collection and looking at provider, patient, or system outcomes). I am interested in helping resident who have an interest in the VA population either primarily or as in a comparison population to create project that take advantage of the information they are frequently inputting during their clinical time.

Medical Ethics

Faculty Name: Bernard Lo, M.D. Professor of Medicine Director, Program in Medical Ethics 415-476-5370 FAX 415-476-5020 Research Focus: Medical ethics, particularly decisions at the end of life, ethical issues in clinical research, doctor-patient relationship. Research projects: Ethical issues in clinical trials involving stem cells Is an analysis of issues such as informed consent from donors of reproductive materials, anonymizing specimens for which consent has not been obtained, and scientific and ethical review of stem cell transplantation protocols. Providing medical care as part of clinical trials in developing countries. Is a questionnaire study to determine how investigators in countries where antiretroviral therapy for HIV is not widely available provide care to patients who seroconvert during their study. Housestaff experience with medical errors. Would analyze data already collected from a questionnaire to UCSF medical residents.

Medical Informatics

Faculty Name: Russ Cucina, M.D., MS Subspecialty/Research Focus: Medical informatics and Applied Clinical Information Technology Title of research project/brief description: My interests are in the study of clinical information systems as tools to improve the quality, safety, and efficiency of medical care. The electronic medical record (EMR) at UCSF Medical Center, known as UCare, has transformed the process of care at the hospital. The medical record is more accessible, more complete, more timely, and easier to read; it may also reflect a qualitatively different type of documentation than was created with a paper system. I am interested in mentoring projects that look at the creation, access, use and retrieval of information from UCare, and real-world design features that can aid clinician work with the system.

Nephrology

Faculty Name: Chi-yuan Hsu, MD, MSc Contact Information: hsuchi@medicine.ucsf.edu Subspecialty/Research Focus: Nephrology, clinical research, epidemiology. Title/Description of Research Projects: We will tailor research projects that will be achievable within a resident.s research time frame which also fit within our broad interest in chronic kidney disease epidemiology and outcomes. For examples of recent publications, please see http://medicine.ucsf.edu/nephrology/faculty/hsu.html.

Oncology

Faculty Name: Donald Abrams, M.D. Subspecialty/Research Focus: Oncology Title of Research Project: Cancer in the Homeless Brief Description of Project: Chart review of cancer cases as SFGH in homeless patients; type;treatment;outcome.

Faculty Name: Michelle Melisko MD Subspecialty/Research Focus: Breast Cancer - Brain metastases, Clinical trials for metastatic disease, Immune Dysfunction in Breast Cancer Title of research project: Several projects are possible including: Retrospective chart review investigating weight gain during neoadjuvant chemotherapy and its effect on treatment outcomes. Retrospective chart review of outcomes for patients with leptomeningeal disease in breast cancer. Review of anemia and transfusion requirements in breast cancer patients receiving dose dense chemotherapy Review of anemia and transfusion requirements in breast cancer patients receiving dose dense chemotherapy.

Orthopedics

Faculty Name: David Rempel, M.D., M.P.H. (Professor in Residence) Subspecialty/Research Focus: Occupational Medicine/Hand and arm disorders related to work. Title of Research Project: Biomarkers for Carpal Tunnel Syndrome and Epicondylitis. Brief Description of Project: Evaluate the relationship between serum and urinary cytokines and severity (symptom and function) of carpal tunnel syndrome and epicondylitis. The goal is to identify biomarkers that are predictive of onset or worsening severity of these disorders in order to evaluate treatments and improve case management. Study takes place at the UCSF Hand Clinic and Occupational Medicine clinics in the Bay Area. Contact: drempel@itsa.ucsf.edu

Pulmonary

Faculty Name: Hall Collard Contact Information: 415-206-4694 (phone); 415-443-4520 (pager);hcollard@medsfgh.ucsf.edu (email) Subspecialty/Research Focus: Interstitial lung disease Title of Research Project: My research program has focused on clinical projects involving subjects with interstitial lung disease, particularly idiopathic pulmonary fibrosis (IPF). I have worked to better understand the natural history of IPF, the clinical and histopathological features clinicians can use to help predict survival, the response of patients with IPF to traditional therapies, and novel ways of sub-classifying patients with this disease. My current focus is on defining the characteristics, etiology and prognosis of acute exacerbations of IPF. Other recent projects include a survey of patient perceptions regarding the management of IPF and an analysis of the diagnostic utility of screening rheumatologic tests in subjects presenting with diffuse lung disease. I am a co-investigator for UCSF in the NIH-sponsored IPF Clinical Research Network that is currently developing multi-center trials for the treatment of IPF. I have had a central role in the generation of one of the networkÕs initial protocols studying the use of sildenafil in advanced Idiopathic Pulmonary Fibrosis.

Faculty Name: Laurence Huang, M.D. Professor of Medicine Chief, AIDS Chest Clinic San Francisco General Hospital Mailing Address: HIV/AIDS Division, Ward 84 San Francisco General Hospital 995 Potrero Avenue San Francisco, CA 94110 Telephone: (415)476-4082, Extension 406 Text Message: 4154432536@archwireless.net Fax: (415) 476-6953 E-mail: Lhuang@php.ucsf.edu Subspecialty/Research Focus: HIV- Associated Pulmonary Disease, Pneumocystis Pneumonia (PCP) Title of Research Project:Molecular Epidemiology Studies of Pneumocystis Pneumonia Brief description of research project: Dr. Huang's main clinical and clinical research interests are in HIV-associated pulmonary disease and especially Pneumocystis pneumonia (PCP). He has collaborations with researchers at the National Institutes of Health, the University of Cincinnati, Makerere University (in Kampala, Uganda), the University of Pittsburgh, and Yale University as well as independent studies on PCP and ICU outcomes among HIV-infected patients. Current research studies include: Development and validation of several new molecular applications to PCP, including the use of a quantitative PCR assay on oropharyngeal wash specimens to diagnose PCP and development of Pneumocystis antibody assays to study Pneumocystis epidemiology and transmission. Comprehensive molecular-epidemiology study to address the question of whether PCP in humans results from person-to-person transmission (as has been convincingly demonstrated from animal-to-animal laboratory studies) and whether disease results from reactivation of latent infection or from recent exposure and infection. Prospective cohort study of the incidences, persistence, and consequences of Pneumocystis colonization both for the individual under study as well as for the potential as a reservoir for the organism. Prospective cohort study of the incidence and persistence of Pneumocystis colonization among health care workers (HCW). Creation of an international clinical research network to study HIV-associated pulmonary diseases worldwide.

Faculty Name: Michael A. Matthay, M.D. Subspecialty/Research Focus: Pulmonary/Critical Care Title of Research Project: Clinical and also lab based studies of acute lung injury. Brief Description: Studies of biological markers in plasma and edema fluid of patients with acute lung injury or more basic lab.

Faculty Name: Homer Boushey, M.D. Subspecialty/Research Focus: Pulmonary Medicine/viral respiratory infection, novel treatment Title of research project: Inhaled NO as Treatment of Viral Respiratory Infection Brief description of research project: This pilot will examine the effects of three brief treatments with inhaled NO (160 ppmx15-30min) on three consecutive days on the severity and duration of symptoms associated with viral respiratory infection. Subjects will be healthy adults who have contracted a viral URI within the preceding 4 days. They will be seen as outpatients for all visits. Assessment of symptom severity will be done by standard questionnaire and diaries; the viral etiology of the cold will be identified by standard methods of culture and PCR; air or NO treatment will be given by nasal mask inhalation in a double-blind randomized manne. Followup assessment will be done at 7-10 and 14-17 days after the final treatment. The Resident's role would be to participate in all phases of interaction with the subjects, and, as permitted by his/her schedule, in data analysis, interpretation, and presentation.

Faculty Name: Mark D. Eisner, MD, MPH Contact Information: Mark.eisner@ucsf.edu 476-7351 Subspecialty/Research Focus: Epidemiology and health outcomes in obstructive lung disease Title/Description of Research Projects: Disability and health outcomes in COPD The natural history of severe asthma Smoking and secondhand smoke exposure -- the impact on respiratory and cardiovascular outcomes Environmental exposures and respiratory disease outcomes

Faculty Name: Laurence Huang, M.D. Associate Professor of Medicine Chief, AIDS Chest Clinic San Francisco General Hospital Mailing address: Positive Health Program, Ward 84 San Francisco General Hospital 995 Potrero Avenue San Francisco, CA 94110 Telephone: (415) 476-4082 extension 406 Fax: (415) 476-6953 E-mail: Lhuang@php.ucsf.edu Subspecialty/Research Focus: HIV- Associated Pulmonary Disease, Pneumocystis Pneumonia (PCP) Title of research project: Molecular Epidemiology Studies of Pneumocystis Pneumonia Brief description of research project: Dr. Huang's main clinical and clinical research interests are in HIV-associated pulmonary disease and especially Pneumocystis pneumonia (PCP). He has several collaborations with researchers at the Centers for Disease Control and Prevention, the National Institutes of Health, the University of Cincinnati, the University of Alabama- Birmingham and the University of Southern California as well as independent studies on PCP and ICU outcomes among HIV-infected patients. Current research studies include: A multicenter molecular-epidemiology study investigating the association between Pneumocystis prophylaxis, Pneumocystis cannot be cultured, this study seeks to address the question of whether human Pneumocystis develops evidence of resistance to PCP treatment and prophylaxis regimens. Development and validation of several new molecular applications to PCP, including the use of a quantitative PCR assay and a novel RT-PCR molecular viability assay on oropharyngeal wash specimens to diagnose PCP, development of Pneaumocystis antibody assays, and development of a .cytokine flow cytometry. assay to detect Pneumocystisspecific CD4+ and CD8+ T cell immune responses. Comprehensive molecular-epidemiology study to address the question of whether PCP in humans results from person-to-person transmission (as has been convincingly demonstrated from animal-to-animal laboratory studies) and whether disease results from reactivation of latent infection or from recent exposure and infection. Prospective cohort study of the incidences, persistence, and consequences of Pneumocystis colonization both for the individual under study as well as for the potential as a reservoir for the organism. Prospective cohort study of the incidence and persistence of Pneumosystis colonization among health care workers (HCW). Creation of an international Pneumocystis network to enable researchers to pool resources and share data to answer questions of mutual interest and to estimate the contribution of PCP to morbidity and mortality in HIV-infected persons worldwide.

Faculty Name: Prescott G. Woodruff, MD, MPH Contact information: Phone (415) 514-2061 UCSF Address: Box 0111, Moffitt Hospital Rm M1098 Email: prescott.woodruff@ucsf.edu Webpage: http://pulmonary.ucsf.edu/faculty/woodruff.html Subspecialty/Research Focus: Pulmonary Medicine Asthma COPD Title/Description of Research Projects: My research activity encompasses both clinical and bench research into the mechanisms of diseases of the airways and, consequently, much of it falls under the rubric of "translational research". In these studies, I am interested in understanding the mechanisms of inflammation, airway remodeling, and airway hyper-responsiveness in asthma and chronic obstructive pulmonary disease. These studies are performed in the Airway Clinical Research Center here at UCSF and in the General Clinical Research Unit at the UCSF Parnassus campus where I am an investigator. A major focus of my recent work has been gene expression profiling in tissues obtained at fiberoptic bronchoscopy. Recent applications have included studies of airway smooth muscle structure and phenotype in airway diseases and studies of alveolar macrophage activation in smoking related lung disease. From the purely clinical research perspective, I am a Co-investigator in the NIH/NHLBI COPD Clinical Research Network which is currently designing protocols for multicenter-clinical trials in the therapy of COPD.