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3 A B C D E F G H I K L M N O P R S T V W Y
Jane Koehler Lab
Research in my laboratory is focused on defining molecular aspects of Bartonella pathogenesis. Bartonellae are fastidious, gram-negative bacteria that cause opportunistic infection in AIDS patients or cat scratch disease in immunocompetent individuals. Bartonella alternately occupies two disparate niches: either the gastrointestinal tract of poikilothermic, obligately hematophagous arthropods (fleas, lice) where it is attached to the epithelial cells, or the bloodstream of homeothermic mammals (humans, cats) where it is attached to/within erythrocytes or endothelial cells. To survive and persist in these two different niches, bartonellae must induce expression of a different repertoire of genes in response to environmental cues.
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