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3 A B C D E F G H I K L M N O P R S T V W Y
Eric Brown Lab
Locomotion, phagocytosis, and adhesion are highly regulated processes in leukocytes. We study the molecular mechanisms underlying these processes and their regulation. We have been particularly interested in integrins, which are molecules involved in cell-cell recognition and cell attachment to extracellular matrix for virtually every cell in the body. About half the laboratory studies the pathogenesis of Mycobacterial infections using the Mycobacterium marinum model. M. marinum causes a tuberculosis-like disease in fish and is genetically closely related to the human pathogen, M. tuberculosis. It also causes a peripheral granulomatous infection in humans, called fish tank granuloma.
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